Somatic Mosaicism across Human Tissues (SMaHT) Program: Genome Characterization Centers (UM1 Clinical Trial Not Allowed)

The purpose of the Somatic Mosaicism across Human Tissues (SMaHT) Network is to advance the discovery of biological processes and disease mechanisms mediated by somatic mutations in human tissues. Since 2023, the program has generated multi-omic somatic mutation datasets from a standardized set of human tissues spanning all three germ layers. Building on the Stage 1 foundation, the NIH intends to issue a Notice of Funding Opportunity (NOFO) seeking support for Stage 2 of the SMaHT Genome Characterization Centers (GCCs) initiative. The SMaHT Stage 2 GCCs will determine the functional consequences of somatic mutations in healthy and clinically relevant tissue samples, the latter comprising patients whose phenotype is suspected to be driven by somatic mutations. This work will support the SMaHT Network's efforts to characterize somatic mosaicism and its role in human biology and disease.